Cardiovascular function of hagfish in anoxia (no oxygen) environments

The vast majority of vertebrate hearts can survive only minutes when cut off from oxygen.

In this study, and in conjunction with my work on cardiovascular responses to anoxia in hagfish, I discovered a number of diverse cardiovascular and biochemical phenotypes that permitted the survival of hagfish for >36h of complete oxygen deprivation.

I discovered that hagfish were able to maintain routine metabolic rate for up to 6 hours of anoxia and that they subsequently utilized metabolic rate suppression to survive anoxic exposure.

By using metabolic rate suppression hagfish met energy requirement using only their glycolytic capacity.

I further discovered that in order to circulate the necessary glycolytic substrates and remove metabolic waste products from tissues the heart maintained function during anoxia. This was a particular surprise as cardiovascular function has traditionally been viewed as highly reliant on a stable oxygen supply.

My research in hagfish has lead to collaborations with other investigators that have since used hagfish to investigate physiological mechanisms of hypoxia and anoxia tolerance, and cardiovascular control mechanisms.


. Introducing a novel mechanism to control heart rate in the ancestral Pacific hagfish. J Exp Biol., 2016.

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. Characterizing the metabolic capacity of the anoxic hagfish heart.. J Exp Biol., 2015.

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. The beat goes on: Cardiac pacemaking in extreme conditions.. Comp Biochem Physiol A Mol Integr Physiol., 2015.

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. A Perspective on the Evolution of the Coronary Circulation in Fishes and the Transition to Terrestrial Life. Ontogeny and Phylogeny of the Vertebrate Heart pp 75-102, 2012.

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. Anoxic survival of the Pacific hagfish (Eptatretus stoutii). J Comp Physiol B., 2011.

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. Cardiac responses to anoxia in the Pacific hagfish, Eptatretus stoutii.. J Exp Biol., 2010.

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. Circulatory limits to oxygen supply during an acute temperature increase in the Chinook salmon (Oncorhynchus tshawytscha). Am J Physiol Regul Integr Comp Physiol 295: R1631–R1639, 2008.

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Getting to the heart of the matter: oxygen supply and demand in fish.
Apr 23, 2018 1:00 PM